Skin irritation and corrosion.
نویسندگان
چکیده
منابع مشابه
Alternative methods for skin irritation testing: the current status.
The potential for chemicals to cause skin corrosion or skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. The determination of skin corrosion and irritation potential is therefore included in international regulatory requirements for the testing of chemicals. The standard approach used involves applying the test ma...
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To clarify the health risks related to silver nanoparticles (Ag-NPs), we evaluated the genotoxicity, acute oral and dermal toxicity, eye irritation, dermal irritation and corrosion and skin sensitisation of commercially manufactured Ag-NPs according to the OECD test guidelines and GLP. The Ag-NPs were not found to induce genotoxicity in a bacterial reverse mutation test and chromosomal aberrati...
متن کاملSkin corrosion and irritation test of sunscreen nanoparticles using reconstructed 3D human skin model
OBJECTIVES Effects of nanoparticles including zinc oxide nanoparticles, titanium oxide nanoparticles, and their mixtures on skin corrosion and irritation were investigated by using in vitro 3D human skin models (KeraSkin ((TM)) ) and the results were compared to those of an in vivo animal test. METHODS Skin models were incubated with nanoparticles for a definite time period and cell viability...
متن کاملSkin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM
Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDermTM skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time...
متن کاملECVAM key area topical toxicity: Update on activities
The European Cosmetics Directive and REACH have accelerated the need for alternative tests. Especially the animal testing ban of cosmetic ingredients from 2009 strongly impacts on the timely delivery of relevant methods. ECVAM's key area "topical toxicity" focuses on skin and eye irritation/corrosion, phototoxicity and percutaneous absorption. Regulatory accepted alternative tests are available...
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عنوان ژورنال:
- Alternatives to laboratory animals : ATLA
دوره 33 Suppl 1 شماره
صفحات -
تاریخ انتشار 2005